CHM 抗体
Quick Overview for CHM 抗体 (ABIN6719537)
抗原
See all CHM 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-CHM Antibody Picoband®
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序列
- QDQILENEEA IALSRKDKTI QHVEVFCYAS QDLHED
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CHM Antibody Picoband® (ABIN6719537). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human CHM, which shares 88.9% amino acid (aa) sequence identity with both mouse and rat CHM.
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亚型
- IgG
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anti-Choroideremia (Rab Escort Protein 1) (CHM) (C-Term) antibody
CHM 适用: 人, 大鼠, 小鼠, 马, 绵羊, 兔, Pig, 猴, Hamster, 豚鼠, 山羊, 驴, 犬, Cow, 小鸡, Cat, Avian WB 宿主: 山羊 Polyclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (AA 1-653) antibodyCHM 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (AA 1-80) antibodyCHM 适用: 人, 大鼠, 小鼠, 马, 绵羊, 兔, Pig, 猴, Hamster, 豚鼠, 山羊, 驴, 犬, Cow, 小鸡, Cat, Avian WB 宿主: 山羊 Polyclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (AA 35-84) antibodyCHM 适用: 人, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (AA 120-210) antibodyCHM 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) antibodyCHM 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (N-Term) antibodyCHM 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (AA 292-320) antibodyCHM 适用: 人 WB 宿主: 兔 Polyclonal RB42411 unconjugated
anti-Choroideremia (Rab Escort Protein 1) (CHM) (N-Term) antibodyCHM 适用: 人, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL
Immunocytochemistry/Immunofluorescence, 5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1. "Entrez Gene: CHM choroideremia (Rab escort protein 1)". 2. Molloy CM, van de Pol TJ, Brohet RM, Ropers HH, Cremers FP (May 1992). "Three RFLPs for pZ11 (DXS540) in the choroideremia gene at Xq21.2". Nucleic Acids Res. 20 (6): 1434. -
说明
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Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CHM (Choroideremia (Rab Escort Protein 1) (CHM))
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别名
- CHM
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背景
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Synonyms: Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, REP-1, TCD protein, CHM, REP1, TCD
Tissue Specificity: Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.
Background: Rab escort protein 1 (REP1) also known as rab proteins geranylgeranyltransferase component A 1 is an enzyme that in humans is encoded by the CHM gene. It is mapped to Xq21.2. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.
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分子量
- 100 kDa
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基因ID
- 1121
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UniProt
- P24386
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途径
- Sensory Perception of Sound
抗原
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