CIC 抗体 (AA 1433-1527)
Quick Overview for CIC 抗体 (AA 1433-1527) (ABIN6719536)
抗原
See all CIC 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1433-1527
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原理
- Anti-CIC Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-CIC Antibody (ABIN6719536). Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human CIC recombinant protein (Position: E1433-Q1527).
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亚型
- IgG
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anti-Capicua Homolog (CIC) (N-Term) antibody
CIC 适用: 小鼠, 人, 大鼠, Cow, 犬, 豚鼠, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Capicua Homolog (CIC) (AA 1475-1560) antibodyCIC 适用: 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Capicua Homolog (CIC) (N-Term) antibodyCIC 适用: 小鼠, 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Capicua Homolog (CIC) (AA 174-203), (N-Term) antibodyCIC 适用: 小鼠, 人 WB, IHC (p) 宿主: 兔 Polyclonal RB24284 unconjugated
anti-Capicua Homolog (CIC) (AA 177-207), (N-Term) antibodyCIC 适用: 小鼠, 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA, 0.1-0.5 μg/mL
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说明
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Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CIC (Capicua Homolog (CIC))
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别名
- CIC
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背景
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Synonyms: Protein capicua homolog, CIC, KIAA0306
Tissue Specificity: Expressed in fetal brain.
Background: Protein capicua homolog is a protein that in humans is encoded by the CIC gene. The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. This gene is mapped to 19q13.2. Alternative splicing results in multiple transcript variants encoding different isoforms.
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分子量
- 55 kDa
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基因ID
- 23152
抗原
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