Caveolin-1 抗体 (AA 4-178)
Quick Overview for Caveolin-1 抗体 (AA 4-178) (ABIN6719534)
抗原
See all Caveolin-1 (CAV1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 4-178
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原理
- Anti-Caveolin-1/CAV1 Antibody Picoband® (monoclonal, 12C7)
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Caveolin-1/CAV1 Antibody Picoband® (monoclonal, 12C7) (ABIN6719534). Tested in IF, IHC, IHC-F, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Caveolin-1 recombinant protein (Position: G4-I178). Human Caveolin-1 shares 95% and 94% amino acid (aa) sequence identity with mouse and rat Caveolin-1, respectively.
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亚型
- IgG2a
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anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (N-Term) antibody
KO Validated CAV1 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 2-104) antibodyCAV1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 2-104) antibodyCAV1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 2-105) antibodyCAV1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (Internal Region) antibodyVerified CAV1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 1-100) antibodyCAV1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 2-120) antibodyCAV1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 4-178) antibodyCAV1 适用: 人, 大鼠, 小鼠 WB, IHC, IF, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (AA 4-178) antibodyCAV1 适用: 人, 小鼠 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (N-Term) antibodyCAV1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunohistochemistry (Frozen Section), 0.5-1 μg/mL
Immunofluorescence, 2 μg/mL1. Tahir, S. A., Yang, G., Ebara, S., Timme, T. L., Satoh, T., Li, L., Goltsov, A., Ittmann, M., Morrisett, J. D., Thompson, T. C.Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer.Cancer Res. 61: 3882-3885, 2001. 2. Wang, X. M., Zhang, Y., Kim, H. P., Zhou, Z., Feghali-Bostwick, C. A., Liu, F., Ifedigbo, E., Xu, X., Oury, T. D., Kaminski, N., Choi, A. M. K.Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis.J. Exp. Med. 203: 2895-2906, 2006. 3. Yang, G., Truong, L. D., Timme, T. L., Ren, C., Wheeler, T. M., Park, S. H., Nasu, Y., Bangma, C. H., Kattan, M. W., Scardino, P. T., Thompson, T. C.Elevated expression of caveolin is associated with prostate and breast cancer.Clin. Cancer Res. 4: 1873-1880, 1998. -
说明
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Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))
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别名
- CAV1
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背景
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Synonyms: Caveolin-1, CAV1, CAV
Tissue Specificity: Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.
Background: CAV1 ( Caveolin-1) is a protein that in humans is encoded by the CAV1 gene. The CAV1 gene is mapped to 7q31.2. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
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分子量
- 22 kDa
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基因ID
- 857
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UniProt
- Q03135
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途径
- Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals
抗原
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