RP2 抗体 (AA 244-348)
Quick Overview for RP2 抗体 (AA 244-348) (ABIN6719513)
抗原
See all RP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 244-348
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原理
- Anti-RP2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-RP2 Antibody Picoband® (ABIN6719513). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human RP2 recombinant protein (Position: D244-M348).
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亚型
- IgG
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anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (AA 251-350) antibody
RP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5C10 unconjugated
anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (AA 251-350) antibodyRP2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1B4 unconjugated
anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (AA 1-350) antibodyRP2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (AA 1-350) antibodyRP2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (C-Term) antibodyRP2 适用: 人, 小鼠, 大鼠, 犬, 兔, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (AA 1-350) antibodyRP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2) (Middle Region) antibodyRP2 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Chapple, J. P., Hardcastle, A. J., Grayson, C., Spackman, L. A., Willison, K. R., Cheetham, M. E.Mutations in the N-terminus of the X-linked retinitis pigmentosa protein RP2 interfere with the normal targeting of the protein to the plasma membrane. Hum. Molec. Genet. 9: 1919-1926, 2000. 2. Evans, R. J., Schwarz, N., Nagel-Wolfrum, K., Wolfrum, U., Hardcastle, A. J., Cheetham, M. E.The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium. Hum. Molec. Genet. 19: 1358-1367, 2010. -
说明
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Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg NaN3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- RP2 (Retinitis Pigmentosa 2 (X-Linked Recessive) (RP2))
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别名
- RP2
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背景
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Synonyms: Protein XRP2, RP2
Tissue Specificity: Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in the bipolar, horizontal and amacrine cells in the inner nuclear layer (INL), extending to the inner plexiform layer (IPL) and though the ganglion cell layer (GCL) and into the nerve fiber layer (NFL) (at protein level).
Background: Protein XRP2 is a protein that in humans is encoded by the RP2 gene. It is mapped to Xp11.3. The RP2 locus has been implicated as one cause of X-linked retinitis pigmentosa. The predicted gene product shows homology with human cofactor C, a protein involved in the ultimate step of beta-tubulin folding. Progressive retinal degeneration may therefore be due to the accumulation of incorrectly folded photoreceptor or neuron-specific tubulin isoforms followed by progressive cell death. The RP2 protein is also involved in regulating the function and extension of outer segment of cone photoreceptors in mice.
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分子量
- 40 kDa
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基因ID
- 6102
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UniProt
- O75695
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途径
- Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process
抗原
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