NPBWR1 抗体 (AA 58-328)
Quick Overview for NPBWR1 抗体 (AA 58-328) (ABIN6719427)
抗原
See all NPBWR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 58-328
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原理
- Anti-GPCR GPR7/NPBWR1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-GPCR GPR7/NPBWR1 Antibody Picoband® (ABIN6719427). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human GPCR GPR7/NPBWR1 recombinant protein (Position: V58-A328).
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亚型
- IgG
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anti-Neuropeptides B/W Receptor 1 (NPBWR1) (Extracellular Domain) antibody
NPBWR1 适用: 人, 大鼠 IHC (p), IHC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) (Cytoplasmic Domain) antibodyNPBWR1 适用: 人, 猴 IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) (Cytoplasmic Domain) antibodyNPBWR1 适用: 人 ELISA, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) (C-Term) antibodyNPBWR1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Neuropeptides B/W Receptor 1 (NPBWR1) antibodyNPBWR1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Hondo M., Ishii M., Sakurai T. (2008). The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion. Results Probl. Cell Differ. 46, 239-256. 2. Nagata-Kuroiwa R., Furutani N., Hara J., Hondo M., Ishii M., Abe T., et al. (2011). Critical role of neuropeptides B/W receptor 1 signaling in social behavior and fear memory. PLoS ONE 6:e16972. -
说明
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Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- NPBWR1 (Neuropeptides B/W Receptor 1 (NPBWR1))
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别名
- NPBWR1
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背景
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Synonyms: Neuropeptides B/W receptor type 1, G-protein coupled receptor 7, NPBWR1, GPR7
Tissue Specificity: Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea, at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.
Background: Neuropeptides B/W receptor 1, also known as NPBW1 and GPR7, is a human protein encoded by the NPBWR1 gene. In rodent models, NPBWR1 is over-expressed in Schwann cells associated with neuropathic pain, suggesting it inhibits inflammatory pain responses. Mice without NPBW1 exhibited a stronger hostile reaction to intruders, suggesting NPBW1 has a role in stress responses. Early studies indicated that NPB and NPW had a complex effect on appetite, but generally led to anorexia. Similarly, male rats lacking NPBWR1 exhibited hyperphagiaand adult-onset obesity, though why female rats are unaffected is unknown. Researchers speculated that activating these pathways might decrease obesity, and synthesized a small-molecule ligand that is capable of stimulating both receptors at low concentrations.
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分子量
- 43 kDa
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基因ID
- 2831
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UniProt
- P48145
抗原
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