Integrin Alpha2b 抗体 (AA 32-263) (DyLight 550)
Quick Overview for Integrin Alpha2b 抗体 (AA 32-263) (DyLight 550) (ABIN7354584)
抗原
See all Integrin Alpha2b (CD41) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 32-263
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原理
- Anti-Human ITGA2B DyLight® 550 conjugated Antibody
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Human ITGA2B DyLight® 550 conjugated Antibody -Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human ITGA2B recombinant protein (Position: L32-D263).
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亚型
- IgG
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anti-Integrin Alpha2b (CD41) (AA 45-149) antibody
CD41 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 2E10C9 unconjugated
anti-Integrin Alpha2b (CD41) (AA 45-149) antibodyCD41 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Integrin Alpha2b (CD41) (AA 351-450) antibodyCD41 适用: 人, 大鼠 FACS, WB, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Integrin Alpha2b (CD41) antibodyCD41 适用: 小鼠 FACS, ELISA, IP, IHC (fro), IHC (p), Func 宿主: 大鼠 Monoclonal MWReg30 unconjugated
anti-Integrin Alpha2b (CD41) antibodyCD41 适用: 小鼠 FACS, ELISA, IP, IHC (fro), IHC (p) 宿主: 大鼠 Monoclonal MWReg30 unconjugated
anti-Integrin Alpha2b (CD41) antibodyCD41 适用: 人, Non-Human Primate FACS, IHC (fro) 宿主: 小鼠 Monoclonal HIP2 unconjugated
anti-Integrin Alpha2b (CD41) antibody (Biotin)CD41 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-06 Biotin
anti-Integrin Alpha2b (CD41) antibody (FITC)CD41 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-06 FITC
anti-Integrin Alpha2b (CD41) (AA 677-711), (C-Term) antibodyCD41 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Integrin Alpha2b (CD41) (AA 639-887) antibodyCD41 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Flow Cytometry (Fixed), 1-3 μg/1x106 cells1. "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". 2. Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3.". Curr. Opin. Hematol. 4(5): 317-22. 3. Quinn MJ, Byzova TV, Qin J et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52.
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说明
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Other applications have not been tested. Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
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- Integrin Alpha2b (CD41)
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别名
- ITGA2B
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背景
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Synonyms: Integrin alpha-IIb, GPalpha IIb, GPIIb, Platelet membrane glycoprotein IIb, CD41, Integrin alpha-IIb heavy chain, Integrin alpha-IIb light chain, form 1, Integrin alpha-IIb light chain, form 2, ITGA2B, GP2B, ITGAB
Tissue Specificity: Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974).
Background: Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. It is mapped to 17q21.32. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
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分子量
- 39 kDa
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基因ID
- 3674
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UniProt
- P08514
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途径
- Integrin Complex
抗原
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