CCBP2 抗体 (AA 138-384)
Quick Overview for CCBP2 抗体 (AA 138-384) (ABIN6719286)
抗原
See all CCBP2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 138-384
-
原理
- Anti-D6/ACKR2 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-D6/ACKR2 Antibody Picoband® (ABIN6719286). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human D6/ACKR2 recombinant protein (Position: M138-A384).
-
亚型
- IgG
-
-
anti-Chemokine Binding Protein 2 (CCBP2) (AA 1-384) antibody
CCBP2 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (N-Term) antibodyCCBP2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (N-Term) antibodyCCBP2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 298-328), (C-Term) antibodyCCBP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2838 unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (C-Term) antibodyCCBP2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 335-384) antibodyCCBP2 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (C-Term) antibodyCCBP2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 54-84) antibodyCCBP2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4519 unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (N-Term) antibodyCCBP2 适用: 人, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine Binding Protein 2 (CCBP2) (AA 335-384) antibodyCCBP2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
ELISA, 0.1-0.5 μg/mL
1. Jamieson, T., Cook, D. N., Nibbs, R. J. B., Rot, A., Nixon, C., Mclean, P., Alcami, A., Lira, S. A., Wiekowski, M., Graham, G. J. The chemokine receptor D6 limits the inflammatory response in vivo. Nature Immun. 6: 403-411, 2005. 2. Nibbs, R. J. B., Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D., Graham, G. J. The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J. Clin. Invest. 117: 1884-1892, 2007. -
说明
-
Tested Species: In-house tested species with positive results. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- CCBP2 (Chemokine Binding Protein 2 (CCBP2))
-
别名
- ACKR2
-
背景
-
Synonyms: Atypical chemokine receptor 2, C-C chemokine receptor D6, Chemokine receptor CCR-10, Chemokine receptor CCR-9, Chemokine-binding protein 2, Chemokine-binding protein D6, ACKR2, CCBP2, CCR10, CMKBR9, D6
Tissue Specificity: Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors. Expressed at high levels in Kaposi sarcoma-related pathologies. Expressed on apoptotic neutrophils (at protein level). Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node.
Background: This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members, however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
-
分子量
- 55 kDa
-
基因ID
- 1238
-
UniProt
- O00590
抗原
-
