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SOCS3 抗体 (AA 155-225)

Name: SOCS3 抗体 (AA 155-225)
SKU: ABIN670416
Availability: OutOfStock

This anti-SOCS3 antibody is a 兔多克隆 antibody detecting SOCS3 in ELISA, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 小鼠和大鼠. This Primary Antibody has been cited in 4+ publications.

Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti SOCS3 Polyclonal Antibody, Unconjugated (ABIN670416) at 1:200 followed by conjugation to the secondary antibody and DAB staining (SOCS3 抗体 (AA 155-225))

IHC

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti SOCS3 Polyclonal Antibody, Unconjugated (ABIN670416) at 1:200 followed by conjugation to the secondary antibody and DAB staining (SOCS3 抗体 (AA 155-225))

IHC

2 images

(4 references)

产品编号 ABIN670416

发货至: 中国

Quick Overview for SOCS3 抗体 (AA 155-225) (ABIN670416)

抗原

See all SOCS3 抗体

SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

适用

小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This SOCS3 antibody is un-conjugated

应用范围

ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product SOCS3 Primary Antibody

抗原表位
23

6

3

3

2

2

2

2

1

1

1

1

1

1

1
AA 155-225

交叉反应

小鼠, 大鼠

预测反应

Human,Dog,Cow,Pig,Chicken,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Socs 3

亚型

IgG
anti-Suppressor of Cytokine Signaling 3 (SOCS3) (C-Term) antibody
SOCS3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) antibody
SOCS3 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E4 unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (C-Term) antibody
SOCS3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-224) antibody
SOCS3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-226) antibody
SOCS3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E4 unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) antibody
SOCS3 适用: 人 WB 宿主: 小鼠 Monoclonal SO1 unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (C-Term) antibody
SOCS3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 71-85), (Middle Region) antibody
SOCS3 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) antibody
SOCS3 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Suppressor of Cytokine Signaling 3 (SOCS3) (AA 1-225) antibody
SOCS3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Song, Zhang, Li, Li, An, Cheng, Guo: "Dynamic expression of the suppressor of cytokine signaling-3 and cytokines in the cerebral basilar artery of rats with subarachnoid hemorrhage, and the effect of acetylcholine." in: Acta neurochirurgica, Vol. 156, Issue 5, pp. 941-9; discussion 949, (2014) (PubMed).

Kou, Hu, Yao, Wang, Shen, Kang, Hong: "Transforming growth factor-?1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment." in: Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol. 62, Issue 3, pp. 283-9, (2013) (PubMed).

Zhu, Dai, Han, He, Mo, Chen, Chen, Wu, Yang, Jiang, Chen, Sun, Zhong: "Expression of SOCSs in human prostate cancer and their association in prognosis." in: Molecular and cellular biochemistry, Vol. 381, Issue 1-2, pp. 51-9, (2013) (PubMed).

Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: "CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine." in: Biochemical and biophysical research communications, Vol. 402, Issue 3, pp. 507-14, (2010) (PubMed).
抗原

SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

别名

SOCS3

背景

Synonyms: CIS3, SSI3, ATOD4, Cish3, SSI-3, SOCS-3, Suppressor of cytokine signaling 3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3
Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp13, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

分子量

25kDa

基因ID

9021

UniProt

O14543

途径

JAK/STAT Signaling, Response to Growth Hormone Stimulus, Hepatitis C