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SNCA 抗体 (HRP)

SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal HRP
产品编号 ABIN6698745
发货至: 中国
  • 抗原 See all SNCA 抗体
    SNCA (Synuclein, alpha (SNCA))
    适用
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    人, 大鼠, 小鼠
    宿主
    • 247
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    克隆类型
    • 231
    • 127
    多克隆
    标记
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    This SNCA antibody is conjugated to HRP
    应用范围
    • 249
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    Western Blotting (WB), ELISA
    特异性
    Detects ~14.46kda.
    纯化方法
    Protein A Purified
    免疫原
    Synthetic peptide from the full length of Human Alpha Synuclein
    Top Product
    Discover our top product SNCA Primary Antibody
  • 应用备注
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    说明

    A 1:1000 dilution of ABIN6698745 was sufficient for detection of Alpha Synuclein in 15 μg of mouse Brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS pH 7.4, 50 % glycerol, 0.09 % Sodium Azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    SNCA (Synuclein, alpha (SNCA))
    别名
    Alpha Synuclein (SNCA 产品)
    别名
    snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
    背景
    Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
    基因ID
    6622
    NCBI登录号
    NP_000336
    途径
    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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