GABBR1 抗体 (AA 651-750)
Quick Overview for GABBR1 抗体 (AA 651-750) (ABIN669756)
抗原
See all GABBR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 651-750
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Dog,Cow,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human GABABR1
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亚型
- IgG
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anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 52-151) antibody
GABBR1 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (C-Term) antibodyGABBR1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) antibodyGABBR1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibodyGABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 unconjugated
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (HRP)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 HRP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (FITC)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 FITC
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (Biotin)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 Biotin
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (PE)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 PE
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (PerCP)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 PerCP
anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 873-977) antibody (APC)GABBR1 适用: 大鼠 WB, IF, ICC 宿主: 小鼠 Monoclonal S93A-49 APC
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应用备注
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ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GABBR1 (gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
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别名
- GABABR1
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背景
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Synonyms: GB1, GPRC3A, GABABR1, GABBR1-3, dJ271M21.1.1, dJ271M21.1.2, Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABBR1
Background: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.
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基因ID
- 2550
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UniProt
- Q9UBS5
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途径
- Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process
抗原
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