EGLN3 抗体 (AA 151-239)
Quick Overview for EGLN3 抗体 (AA 151-239) (ABIN669741)
抗原
See all EGLN3 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 151-239
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                                            交叉反应
- 小鼠
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                                            预测反应
- Human,Rat,Dog,Cow,Pig
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                                            纯化方法
- Purified by Protein A.
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                                            免疫原
- KLH conjugated synthetic peptide derived from PHD3
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                                            亚型
- IgG
 
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                                            应用备注
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                        WB 1:300-5000
 ELISA 1:500-1000
 IHC-P 1:200-400
 IHC-F 1:100-500
 IF(IHC-P) 1:50-200
 IF(IHC-F) 1:50-200
 IF(ICC) 1:50-200
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                                            限制
- 仅限研究用
 
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                                            状态
- Liquid
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                                            浓度
- 1 μg/μL
- 
                                            缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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                                            有效期
- 12 months
 
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    - EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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                                            别名
- PHD3
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                                            背景
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                        Synonyms: EGL9 homolog of C. elegans 3, EGLN3, Factor responsive smooth muscle protein, H Prolyl Hydroxylase 3, HP4H3, HPH3, P4H3, Prolyl Hydroxylase Domain Containing Protein 3, SM20, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-PH3, HPH-3. Background: PHD3 (Egl nine homolog 3, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-prolyl hydroxylase 3, HIF-PH3, HPH-1, Egln3, Prolyl hydroxylase domain-containing protein 3,)Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism. [Catalytic Activity] An HIF alpha chain L-proline + 2-oxoglutarate+ O(2) = An HIF alpha chain trans-4-hydroxy-L-proline + succinate + CO(2). [Subcellular Location] Cytoplasm. Nucleus. Widely expressed at low levels. Expressed athigher levels in heart (cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle) and placenta. 
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                                            基因ID
- 112399
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                                            UniProt
- Q9H6Z9
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                                            途径
- Positive Regulation of Endopeptidase Activity
 抗原
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