EGLN3 抗体 (AA 151-239)
Quick Overview for EGLN3 抗体 (AA 151-239) (ABIN669741)
抗原
See all EGLN3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 151-239
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交叉反应
- 小鼠
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预测反应
- Human,Rat,Dog,Cow,Pig
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from PHD3
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亚型
- IgG
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anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-120) antibody
EGLN3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-239) antibodyEGLN3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-120) antibodyEGLN3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 2-239) antibodyEGLN3 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (C-Term) antibodyEGLN3 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 猴, 豚鼠, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 94-193) antibodyEGLN3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) antibodyEGLN3 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 1-239) antibodyEGLN3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (AA 50-100) antibodyEGLN3 适用: 人, 大鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3) (Internal Region) antibodyVerified EGLN3 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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别名
- PHD3
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背景
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Synonyms: EGL9 homolog of C. elegans 3, EGLN3, Factor responsive smooth muscle protein, H Prolyl Hydroxylase 3, HP4H3, HPH3, P4H3, Prolyl Hydroxylase Domain Containing Protein 3, SM20, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-PH3, HPH-3.
Background: PHD3 (Egl nine homolog 3, Hypoxia-inducible factor prolyl hydroxylase 3, HIF-prolyl hydroxylase 3, HIF-PH3, HPH-1, Egln3, Prolyl hydroxylase domain-containing protein 3,)Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism. [Catalytic Activity] An HIF alpha chain L-proline + 2-oxoglutarate+ O(2) = An HIF alpha chain trans-4-hydroxy-L-proline + succinate + CO(2). [Subcellular Location] Cytoplasm. Nucleus. Widely expressed at low levels. Expressed athigher levels in heart (cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle) and placenta.
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基因ID
- 112399
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UniProt
- Q9H6Z9
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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