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DNMT3A 抗体 (AA 26-100) (Cy7)

This anti-DNMT3A antibody is a 兔 多克隆 antibody detecting DNMT3A in FACS, IF (cc) 和 IF (p). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN669342
发货至: 中国

Quick Overview for DNMT3A 抗体 (AA 26-100) (Cy7) (ABIN669342)

抗原

See all DNMT3A 抗体
DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

适用

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人, 小鼠, 大鼠

宿主

  • 120
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克隆类型

  • 111
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多克隆

标记

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This DNMT3A antibody is conjugated to Cy7

应用范围

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Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • 抗原表位

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    AA 26-100

    交叉反应

    人, 小鼠, 大鼠

    预测反应

    Cow

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human Dnmt3a

    亚型

    IgG
  • 应用备注

    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    DNMT3A (DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A))

    别名

    Dnmt3a

    背景

    Synonyms: TBRS, DNMT3A2, M.HsaIIIA, DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA

    Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.

    基因ID

    1788

    UniProt

    Q9Y6K1
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