GABRA6 抗体
Quick Overview for GABRA6 抗体 (ABIN6658222)
抗原
See all GABRA6 抗体适用
宿主
克隆类型
标记
应用范围
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Supplier Product No.
- 100-401-d48
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Supplier
- Rockland
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原理
- GABAA Receptor alpha 6 Antibody
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交叉反应 （详细）
- Anti-GABA(A) Receptor alpha 6 Antibody is directed against rat GABA(A) Receptor alpha 6.
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纯化方法
- The antibody was prepared from monospecific neat serum.
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免疫原
- Anti-GABA(A) Receptor a 6 Antibody was produced by repeated immunizations with rat GABA(A) receptor alpha 6- Synthetic peptide corresponding to amino acid specific to the alpha 6 subunit.
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亚型
- IgG
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anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Internal Region) antibody
GABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (N-Term) antibodyGABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Domain) antibodyGABRA6 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Loop) antibodyGABRA6 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-30) antibodyGABRA6 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-37), (Extracellular) antibodyGABRA6 适用: 大鼠 WB, IHC, IF, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-242) antibodyGABRA6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 15-26) antibodyVerified GABRA6 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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应用备注
- Optional[Neutralization_Dilution]: 1:1000
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说明
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Anti-GABA(A) Receptor alpha 6 (Rabbit) antibody has been tested in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 57 kDa in size corresponding to the alpha 6 subunit of the GABA(A) receptor in the appropriate cell lysate or extract.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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有效期
- 12 months
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- GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
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别名
- GABA(A) Receptor alpha 6
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背景
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Synonyms: Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6
Background: Anti-GABA(A) Receptor alpha 6 Antibody detects GABA(A) Receptor alpha 6. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) receptor alpha 6 antibody is ideal for investigators involved in Neuroscience.
Gene Name: GABRA6
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基因ID
- 29708
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NCBI登录号
- NP_068613
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UniProt
- P30191
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途径
- Synaptic Membrane
抗原
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