GRM7 抗体 (pSer862)
-
- 抗原 See all GRM7 抗体
- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
-
抗原表位
- pSer862
-
适用
- 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This GRM7 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠
- 交叉反应 (详细)
- Cross reactivity with mGluR7 from other species has not been determined.
- 纯化方法
- Anti mGluR7 pS862 antibodiy is directed against mGluR7 phosphorylated at Ser862. GluR7 antibdody is affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide. The antibody is a total IgG fraction. Expect reactivity with the following species based on sequence homology: bovine, canine, human, non-human primate and zebrafish.
- 免疫原
-
Immunogen: Anti-mGluR7 pS862 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser 862 conjugated to KLH.
Immunogen Type: Peptide
- 亚型
- IgG
- Top Product
- Discover our top product GRM7 Primary Antibody
-
-
- 应用备注
-
Application Note: Anti-mGluR7 pS862 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 102 kDa in size corresponding to the mGluR7 protein phosphorylated at Ser862 in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
-
Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
-
- 抗原
- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
- 别名
- mGluR7 (GRM7 产品)
- 别名
- MGLUR7 antibody, GLUR7 antibody, GPRC1G antibody, MGLU7 antibody, 6330570A01Rik antibody, BB176677 antibody, C030018L03 antibody, E130018M02Rik antibody, Gpr1g antibody, Gprc1g antibody, mGluR7 antibody, glutamate metabotropic receptor 7 antibody, glutamate receptor, metabotropic 7 antibody, GRM7 antibody, Grm7 antibody
- 背景
-
Synonyms: mGluR7, Metabotropic Glutamate Receptor 7
Background: mGluR7 pS862 antibodiy detects mGluR7 when phosphorylated at Ser862. Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1. Therefore, mGluR7 pS862 antibody is ideal for investigators involved in neuronal circuitry and more generally in Neuroscience.
Gene Name: GRM7
- 基因ID
- 81672
- UniProt
- P35400
- 途径
- Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour
-