CASK 抗体
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北京 101111
Quick Overview for CASK 抗体 (ABIN6658140)
抗原
See all CASK 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-f02
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Supplier
- Rockland
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原理
- CASK Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with CASK from Mouse, Rat, Human, Zebrafish, and Xenopus based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-CASK Antibody was purified by Protein G chromatography.
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过滤
- Sterile filtered
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免疫原
- CASK Antibody was produced in mice by repeated immunizations with a fusion protein of rat CASK/Lin2.
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亚型
- IgG1
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anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 1-300) antibody
CASK 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 262-291) antibodyCASK 适用: 人 WB 宿主: 兔 Polyclonal RB15769 unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 470-760) antibodyCASK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) antibodyCASK 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (N-Term) antibodyCASK 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 651-750) antibodyCASK 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 564-596), (C-Term) antibodyCASK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1248 unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 589-616) antibodyCASK 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) antibodyCASK 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 1-337) antibodyCASK 适用: 小鼠, 大鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoprecipitation_Dilution: User Optimized
Immunohistochemistry_Dilution: User Optimized
Western_Blot_Dilution: 1:1000
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说明
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Anti-CASK Antibody is tested for use in WB and IHC. Expect a band approximately ~100kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))
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别名
- CASK
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背景
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Synonyms: Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase
Background: CASK (calmodulin sensitive kinase) is a ~112 kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures. While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator. Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births. CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing.
Gene Name: Cask
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基因ID
- 29647
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NCBI登录号
- NP_071520
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UniProt
- Q62915
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途径
- Synaptic Vesicle Exocytosis
抗原
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