INA 抗体
Quick Overview for INA 抗体 (ABIN6658127)
抗原
See all INA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 900-301-d04
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Supplier
- Rockland
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原理
- Alpha Internexin Antibody
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交叉反应 （详细）
- Anti-Alpha Internexin Antibody is directed against rat Alpha Internexin.
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纯化方法
- The antibody is protein G purified from cell culture supernatant.
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免疫原
- Anti-Alpha Internexin Antibody was produced by repeated immunizations with recombinant rat alpha internexin expressed in E. coli.
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亚型
- IgG1
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anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) (Internal Region) antibody
INA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) (AA 251-350) antibodyINA 适用: 人, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) antibodyINA 适用: 大鼠 WB, IHC, IF 宿主: 小鼠 Monoclonal 1D2 unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) antibodyINA 适用: 大鼠 WB, IF 宿主: 小鸡 Polyclonal unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) (AA 71-161) antibodyINA 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) (AA 290-319) antibodyINA 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB13854 unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) (AA 290-319) antibodyINA 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 257CT7-1-2 unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) antibodyINA 适用: 人, 小鼠 WB 宿主: 小鼠 Monoclonal 7T2 unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) antibodyINA 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Internexin Neuronal Intermediate Filament Protein, alpha (INA) antibodyINA 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鸡 Polyclonal unconjugated
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应用备注
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ELISA_Dilution: 1:20,000
Immunohistochemistry_Dilution: 1:1000
IF_Microscopy_Dilution: 1:250
Western_Blot_Dilution: 1:2000
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说明
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Anti-Alpha Internexin antibody is tested for use in ELISA, Western Blotting, IHC and ICC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 66kDa in size corresponding to alpha internexin proteins in the appropriate cell lysate or extract. Anti-Alpha Internexin antibody can be used on formalin-fixed cells in tissue culture, cryostat sections. The epitope recognized by the ID2 clone is in the C-terminal non-helical extension of the protein and is unusually resistant to aldehyde fixation, so that this antibody is ideal for studies of paraffin embedded formalin fixed histological sections.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Optional[Buffer]: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 ,0.01 % (w/v) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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有效期
- 12 months
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- INA (Internexin Neuronal Intermediate Filament Protein, alpha (INA))
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别名
- Alpha Internexin
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背景
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Synonyms: mouse anti-Alpha Internexin Antibody, Alpha INX, internexin, NF-66, NEF5
Background: Anti-Alpha Internexin antibody recognizes alpha-internexin which is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits. Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID), a serious human neurodegenerative disorder. The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity, as well as in some normal individuals. Anti-Alpha Internexin antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Gene Name: INA
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基因ID
- 24503
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UniProt
- P23565
抗原
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