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GRIN2C 抗体 (N-Term)

Rockland 600-401-d94 GRIN2C 适用: 大鼠 WB, IHC, IP, FM 宿主: 兔 Polyclonal unconjugated
Rockland
产品编号 ABIN6658125
Supplier Product No.: 600-401-d94
发货至: 中国
  • 抗原 See all GRIN2C 抗体
    GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
    抗原表位
    • 8
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 34
    • 20
    • 20
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    大鼠
    宿主
    • 46
    • 5
    克隆类型
    • 48
    • 3
    多克隆
    标记
    • 36
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRIN2C antibody is un-conjugated
    应用范围
    • 37
    • 14
    • 11
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
    Supplier Product No.
    600-401-d94
    Supplier
    Rockland
    原理
    NMDA R2C Antibody
    交叉反应 (详细)
    Anti-NMDA R2C antibody is directed against NMDA R2C protein.
    纯化方法
    The antibody was affinity purified from monospecific antiserum by immunoaffinity purification.
    免疫原
    Anti-NMDA R2C Antibody was produced by repeated immunizations with a fusion proteins from the N-terminal region of the NR2C subunit.
    亚型
    IgG
    Top Product
    Discover our top product GRIN2C Primary Antibody
  • 应用备注

    Immunoprecipitation_Dilution: 3 μL per 200 μg lysate

    Immunohistochemistry_Dilution: 1:1000-2000

    IF_Microscopy_Dilution: 1:1000-2000

    Western_Blot_Dilution: 1:1000

    Other: User Optimized

    说明

    Anti-NMDA R2C Antibody is tested for use in Western Blotting and Immunoprecipitation and suitable for IHC and IF. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 140 kDa in size corresponding to the NR2C subunit of the NMDA receptor. This antibody also labels the approximately 180 kDa NR2A and NR2B subunits of the NMDA receptor.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式

    Reconstitution_Buffer: Neutral PBS

    Reconstitution_Volume: 50μL

    储存条件
    4 °C,-20 °C
    储存方法
    Store vial at 4° C prior to restoration.   For extended storage aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  Dilute only prior to immediate use. 
    有效期
    12 months
  • Yoshikawa, Kan, Shirose, Watanabe, Matsuda, Ito, Kawaguchi: "Free d-Amino Acids in Salivary Gland in Rat." in: Biology, Vol. 11, Issue 3, (2022) (PubMed).

  • 抗原
    GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))
    别名
    NMDA R2C (GRIN2C 产品)
    背景

    Synonyms: Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C

    Background: NMDA R2C Antibody detects NMDA R2C protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The NMDAR is also potentiated by protein phosphorylation. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. The NR2C subunit of the receptor is thought to influence the NMDAR conductance level. Anti-NMDA R2C Antibody is ideal for investigators involved in Neuroscience, Signal Transduction, and Cell Signaling Research.

    Gene Name: GRIN2C

    基因ID
    24411
    UniProt
    Q00961
    途径
    Synaptic Membrane
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