SNCA 抗体 (pSer129)
Quick Overview for SNCA 抗体 (pSer129) (ABIN6658101)
抗原
See all SNCA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - pSer129
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Supplier Product No.
 - 612-401-c70
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Supplier
 - Rockland
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原理
 - Alpha Synuclein phospho S129 Antibody
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交叉反应 (详细)
 - Anti-Alpha Synuclein pS129 Antibody is directed against rat Alpha-synuclein phosphorylated at S129.
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纯化方法
 - The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.
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免疫原
 - Anti-Alpha Synuclein pS129 Antibody was produced by repeated immunizations with a synthetic phospho peptide corresponding to amino acid residues surrounding Ser129.
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亚型
 - IgG
 
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应用备注
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ELISA_Dilution: 1:10,000
Western_Blot_Dilution: 1:1000
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说明
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Alpha Synuclein pS129 antibody is tested for use in ELISA, Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 15 kDa in size corresponding to the alpha synuclein protein phosphorylated at Ser129 in the appropriate cell lysate or extract.
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限制
 - 仅限研究用
 
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状态
 - Liquid
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缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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有效期
 - 12 months
 
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- SNCA (Synuclein, alpha (SNCA))
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别名
 - Alpha Synuclein
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背景
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Synonyms: Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor
Background: Alpha Synuclein pS129 Antibody detects Alpha-synuclein phosphorylated at S129. Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD. Anti-Alpha-synuclein pS129 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Gene Name: SNCA
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基因ID
 - 29219
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NCBI登录号
 - NP_062042
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UniProt
 - P37377
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途径
 - Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
 
抗原
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