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SNCA 抗体 (pSer129)

This anti-SNCA antibody is a 兔 多克隆 antibody detecting SNCA in WB 和 ELISA. Suitable for 大鼠.
Rockland
产品编号 ABIN6658101
Supplier Product No.: 612-401-c70
发货至: 中国

Quick Overview for SNCA 抗体 (pSer129) (ABIN6658101)

抗原

See all SNCA 抗体
SNCA (Synuclein, alpha (SNCA))

适用

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大鼠

宿主

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克隆类型

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多克隆

标记

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This SNCA antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA
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    pSer129

    Supplier Product No.

    612-401-c70

    Supplier

    Rockland

    原理

    Alpha Synuclein phospho S129 Antibody

    交叉反应 (详细)

    Anti-Alpha Synuclein pS129 Antibody is directed against rat Alpha-synuclein phosphorylated at S129.

    纯化方法

    The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

    免疫原

    Anti-Alpha Synuclein pS129 Antibody was produced by repeated immunizations with a synthetic phospho peptide corresponding to amino acid residues surrounding Ser129.

    亚型

    IgG
  • 应用备注

    ELISA_Dilution: 1:10,000

    Western_Blot_Dilution: 1:1000

    说明

    Alpha Synuclein pS129 antibody is tested for use in ELISA, Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 15 kDa in size corresponding to the alpha synuclein protein phosphorylated at Ser129 in the appropriate cell lysate or extract.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    储存条件

    4 °C,-20 °C

    储存方法

    Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

    有效期

    12 months
  • 抗原

    SNCA (Synuclein, alpha (SNCA))

    别名

    Alpha Synuclein

    背景

    Synonyms: Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

    Background: Alpha Synuclein pS129 Antibody detects Alpha-synuclein phosphorylated at S129. Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson's disease (PD) and other neurodegenerative disorders. Mutation of the alpha-synuclein gene is associated with familial forms of PD. Recent evidence suggests that phosphorylation of alpha-synuclein at Ser129 plays a role in the formation of inclusions in PD. Anti-Alpha-synuclein pS129 antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

    Gene Name: SNCA

    基因ID

    29219

    NCBI登录号

    NP_062042

    UniProt

    P37377

    途径

    Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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