TNNI3 抗体
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北京 101111
Quick Overview for TNNI3 抗体 (ABIN6658031)
抗原
See all TNNI3 抗体适用
宿主
克隆类型
标记
应用范围
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Supplier Product No.
- 100-401-x31
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Supplier
- Rockland
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原理
- Troponin I (cardiac) Antibody
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纯化方法
- Anti-Troponin (cardiac) Antibody is a prepared sterile filter neat serum.
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过滤
- Sterile filtered
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免疫原
- Anti-Troponin (cardiac) Antibody was produced in rabbits by repeated immunizations with a fusion protein of complete mouse cardiac troponin 1.
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亚型
- IgG
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anti-Cardiac Troponin I (TNNI3) (AA 102-210) antibody
TNNI3 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1E7 unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 1-211) antibodyTNNI3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 2-211) antibodyTNNI3 适用: Pig WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) antibodyTNNI3 适用: 人, 犬, 猴 WB, IF 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 1-211) antibodyTNNI3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 117-127) antibodyVerified TNNI3 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 2-210) antibodyTNNI3 适用: 人 IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) (pSer44) antibodyTNNI3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 1-203) antibodyTNNI3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cardiac Troponin I (TNNI3) (AA 1-210) antibodyTNNI3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA_Dilution: 1:20,000
Western_Blot_Dilution: 1:2000 (or higher in cardiac muscle)
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说明
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Anti-Troponin (cardiac) Antibody has been tested in Western Blots and is specific for the ~25 kDa cardiac troponin I protein. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: None
Stabilizer: None
Preservative: None -
储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
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有效期
- 12 months
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- TNNI3 (Cardiac Troponin I (TNNI3))
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别名
- Troponin I (cardiac)
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背景
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Synonyms: Troponin I cardiac muscle, Cardiac troponin I
Background: Troponin I (cTnI) is 1 of 3 subunits, along with troponin C (TnC) and troponin T (TnT) of troponin complex found in cardiac muscle. cTnI binds to actin in thin myofilaments to hold the troponin-tropomyosin complex in place. Phosphorylation of cardiac isoform of TnI at serines 22,23 in the unique amino-terminal end molecule decreases the calcium sensitivity of the sarcomere, promotes calcium dissociation from troponin C and by extension enhances rates of cross-bridge cycling and diastolic relaxation. In addition, studies using reconstituted fibers and mutational analysis have shown that PKC phosphorylation of TnI (largely at Ser43) inhibits the actin-cross bridge reaction and reduces the Ca++ dependent actomyosin ATPase rate as well as the calcium sensitivity of force generation. Phosphorylation at Thr144 (mediated by several PKC isoforms) reduces maximal tension development and cross-bridge cycling rates. Importantly, changes in the phosphorylation at each of these sites have been shown to be stage-specific with regard to cardiac disease progression. Troponin I Antibody is ideal for researchers interested in cancer research.
Gene Name: TNNI3
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基因ID
- 21954
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NCBI登录号
- NP_033432
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UniProt
- P48787
抗原
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