ZIC1 抗体 (N-Term)
(5 references)
Quick Overview for ZIC1 抗体 (N-Term) (ABIN6657599)
抗原
See all ZIC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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Supplier Product No.
- 200-401-159
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Supplier
- Rockland
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原理
- Zic-1 Antibody
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交叉反应 （详细）
- This antibody is directed against Zic-1 from mouse.
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纯化方法
- This is an IgG preparation of whole rabbit antiserum purified by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.
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过滤
- Sterile filtered
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免疫原
- The whole rabbit serum used to produce this IgG fraction antibody was prepared by repeated immunizations with an 18 aa synthetic peptide from a region near the N-Terminus of mouse Zic-1. This domain is completely conserved in human ZIC-1.
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亚型
- IgG
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anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 139-212) antibody
ZIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 139-212) antibodyZIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D2 unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 2-95) antibodyZIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F7 unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 2-95) antibodyZIC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (N-Term) antibodyZIC1 适用: 小鼠 WB, ELISA, IHC, FM 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 50-99) antibodyZIC1 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, Bat, 小鸡, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (AA 120-210) antibodyZIC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) antibodyZIC1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Zinc Finger Protein ZIC 1 (ZIC1) (N-Term) antibodyZIC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA_Dilution: 1:10,000 - 1:50,000
Immunohistochemistry_Dilution: 1:400
IF_Microscopy_Dilution: 1:400
Western_Blot_Dilution: 1:5,000
Other: User Optimized
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说明
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Suggested Applications: IF, Multiplex
Anti Zic-1 Antibody has been tested by western blotting and for ELISA. Researchers should determine optimal titers for applications that are not stated below. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse." in: Cancer cell, Vol. 36, Issue 3, pp. 302-318.e7, (2020) (PubMed).
: "Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 38, Issue 6, pp. 1575-1587, (2019) (PubMed).
: "Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1." in: Scientific reports, Vol. 6, pp. 37412, (2018) (PubMed).
: "The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma." in: Nature medicine, Vol. 20, Issue 9, pp. 1035-42, (2014) (PubMed).
: "Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development." in: Genes & development, Vol. 22, Issue 6, pp. 722-7, (2008) (PubMed).
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: "Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse." in: Cancer cell, Vol. 36, Issue 3, pp. 302-318.e7, (2020) (PubMed).
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- ZIC1 (Zinc Finger Protein ZIC 1 (ZIC1))
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别名
- Zic-1
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背景
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Synonyms: rabbit anti-Zic-1 Antibody, Odd paired homolog Drosophila antibody, Zic 1 antibody, ZIC antibody, Zic family member 1 (odd-paired Drosophila homolog) antibody, Zic family member 1 antibody
Background: Anti Zic-1 Antibody recognizes the product of the Zic-1 gene, that encodes a zinc finger protein which is expressed in the developing or matured central nervous system in a highly restricted manner. Zic-1 is expressed in granule cells that make synaptic contact with Purkinje cells. Clearly Zic-1 is a gene critical to cerebellar pattern formation. The expression of Zic genes is first detected at gastrulation and at neurulation, becomes restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm. Zic-2 and Zic-3 are highly similar genes, especially in their product's zinc finger motif and by comparison of their genomic organization in that they share common exon-intron boundaries and belong to the same gene family. By comparison in function, Zic-2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation. The Zic-1 gene has been mapped to chromosome 9 in mouse. The 5' flanking region of the Zic-1 gene contains a region-specific enhancer determined to be essential in in vivo and in vitro deletion analysis. The temporal profile of mRNA expression differs for each of the Zic gene products. The Drosophila odd-paired gene is highly homologous to the Zic gene family.
Gene Name: Zic1
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基因ID
- 22771
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UniProt
- P46684
抗原
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