FKBP5 抗体
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北京 101111
Quick Overview for FKBP5 抗体 (ABIN6656088)
抗原
See all FKBP5 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-f28
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Supplier
- Rockland
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原理
- FKBP51 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with FKBP51 from Canine, Hamster, Human, Mouse, Rat, and Rabbit based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-FKBP51 Antibody was purified by Protein G chromatography.
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过滤
- Sterile filtered
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免疫原
- FKBP51 Antibody was produced in mice by repeated immunizations with a synthetic peptide corresponding to the residues of human FKBP51.
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亚型
- IgG1
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anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibody
FKBP5 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 308-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D10-1G11 unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 1-457) antibodyFKBP5 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 3D1-1B10 unconjugated
anti-FK506 Binding Protein 5 (FKBP5) antibodyFKBP5 适用: 人 WB, ICC, IF 宿主: 小鼠 Monoclonal Hi51B unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 201-300) antibodyFKBP5 适用: 小鼠, 大鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-FK506 Binding Protein 5 (FKBP5) (AA 2-457) antibodyFKBP5 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF_Microscopy_Dilution: 10 μg/mL
Western_Blot_Dilution: 1:2000
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说明
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Anti-FKBP51 Antibody is tested for IF and WB. Expect a band approximately ~51kDa protein representing FKBP51 in cell lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
Preservative: 0.09 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- FKBP5 (FK506 Binding Protein 5 (FKBP5))
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别名
- FKBP51
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背景
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Synonyms: AIG6, FK506 binding protein 5, FKBP5, FKBP54, FKBP51, Hsp90 binding immunophilin, p54, Pplase, Ptg10, Rotamase, T cell FK506 binding protein antibody
Background: Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones. One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins. FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex. The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90. Although FKBP52 and FKBP51 share ~75 % sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics . FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids.
Gene Name: FKBP5
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基因ID
- 2289
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NCBI登录号
- NP_001139247
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UniProt
- Q13451
抗原
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