PDIA3 抗体
Quick Overview for PDIA3 抗体 (ABIN6656047)
抗原
See all PDIA3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-301-f26
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Supplier
- Rockland
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原理
- Erp57 (Grp58) Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Erp57 (Grp58) from Human, Mouse, Bovine, Canine, Guinea pig, Hamster, Monkey, Pig, Rabbit, and Rat based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-Erp57 (Grp58) Antibody was purified by Protein G chromatography.
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过滤
- Sterile filtered
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免疫原
- Erp57 (Grp58) Antibody was produced in mice by repeated immunizations with a human Recombinant Erp57 (Grp58).
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亚型
- IgG1
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anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) (C-Term) antibody
PDIA3 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 猴, Cow, 兔, Pig, Hamster, 马, 山羊, 绵羊, Avian, Cat, 小鸡, 驴 WB, IF, IHC (p), IHC (fro) 宿主: 山羊 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) (AA 1-505) antibodyPDIA3 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) (AA 140-505) antibodyPDIA3 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3H5 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) antibodyPDIA3 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3E1 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) (C-Term) antibodyPDIA3 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) antibodyPDIA3 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal Map-ERp57 unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) (AA 1-505) antibodyPDIA3 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) antibody (HRP)PDIA3 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal Map-ERp57 HRP
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) antibody (FITC)PDIA3 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal Map-ERp57 FITC
anti-Protein Disulfide Isomerase Family A, Member 3 (PDIA3) antibody (Biotin)PDIA3 适用: 人 WB, IHC, IF, IP, ICC 宿主: 小鼠 Monoclonal Map-ERp57 Biotin
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应用备注
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Immunoprecipitation_Dilution: User Optimized
Immunohistochemistry_Dilution: User Optimized
Western_Blot_Dilution: 1:2000
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说明
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Anti-EC SOD Antibody has been tested in WB, IP, IF, and IHC. Expect a band approximately ~57kDa in specific lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))
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别名
- Erp57 (Grp58)
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背景
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Synonyms: ERp60, ERp61, Grp57, Grp58, P58, PDIA3, PI PLC, Protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 57, Endoplasmic reticulum resident protein 60
Background: ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs. It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glucosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface. ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus.
Gene Name: PDIA3
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基因ID
- 2923
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NCBI登录号
- NP_005304
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UniProt
- P30101
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途径
- Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis
抗原
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