CRYAB 抗体
Quick Overview for CRYAB 抗体 (ABIN6656044)
抗原
See all CRYAB 抗体适用
宿主
克隆类型
标记
应用范围
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Supplier Product No.
- 100-401-f18
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Supplier
- Rockland
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原理
- Alpha B Crystallin Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Crystallin Alpha B from Human, Mouse, Rat, Cow, and Chicken based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-Crystallin Alpha B Antibody was prepared from monospecific antiserum by delipidation and defibrination.
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过滤
- Sterile filtered
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免疫原
- Crystallin Alpha B Antibody was produced from whole rabbit serum prepared by repeated immunizations with a synthetic peptide corresponding to human alpha B crystallin.
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亚型
- IgG
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anti-Crystallin, alpha B (CRYAB) (AA 1-175) antibody
CRYAB 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha B (CRYAB) antibodyCRYAB 适用: 人 WB, IHC, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 6G5 unconjugated
anti-Crystallin, alpha B (CRYAB) antibodyCRYAB 适用: 人, 大鼠 WB, IHC, StM 宿主: 小鼠 Monoclonal CPTC-CRYAB-1 unconjugated
anti-Crystallin, alpha B (CRYAB) (AA 1-175) antibodyCRYAB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha B (CRYAB) antibodyCRYAB 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Crystallin, alpha B (CRYAB) (AA 1-175) antibodyCRYAB 适用: 人 ELISA, IHC 宿主: 小鼠 Monoclonal 1D11C6E6 unconjugated
anti-Crystallin, alpha B (CRYAB) antibody (HRP)CRYAB 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal HRP
anti-Crystallin, alpha B (CRYAB) antibody (FITC)CRYAB 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal FITC
anti-Crystallin, alpha B (CRYAB) antibody (HRP)CRYAB 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 小鼠 Monoclonal 3A10-C9 HRP
anti-Crystallin, alpha B (CRYAB) antibody (Biotin)CRYAB 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal Biotin
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应用备注
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Immunohistochemistry_Dilution: User Optimized
Western_Blot_Dilution: 1:5000-10000
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说明
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Anti-Crystallin Alpha B Antibody is suitable for use in WB, IHC and IF microscopy. Expect a band approximately ~22kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- CRYAB (Crystallin, alpha B (CRYAB))
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别名
- Crystallin Alpha B
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背景
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Synonyms: AACRYA, Alpha crystallin B chain, CRYA2, CRYAB, CTPP2, HspB5, NY REN 27 antigen, Rosenthal fiber component, Renal carcinoma antigen NY-REN-27, Heat shock protein beta-5
Background: The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27. Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance. In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA. Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases. Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions.
Gene Name: CRYAB
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基因ID
- 1410
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NCBI登录号
- NP_001876
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UniProt
- P02511
抗原
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