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THRB 抗体 (N-Term)

This anti-THRB antibody is a 小鼠 单克隆 antibody detecting THRB in WB. Suitable for 人. This Primary Antibody has been cited in 2+ publications.
Rockland
产品编号 ABIN6655581
Supplier Product No.: 209-301-a96
发货至: 中国

Quick Overview for THRB 抗体 (N-Term) (ABIN6655581)

抗原

See all THRB 抗体
THRB (Thyroid Hormone Receptor, beta (THRB))

适用

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宿主

  • 58
  • 6
  • 1
小鼠

克隆类型

  • 59
  • 6
单克隆

标记

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This THRB antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

2386
  • 抗原表位

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    • 1
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    N-Term

    Supplier Product No.

    209-301-a96

    Supplier

    Rockland

    原理

    Thyroid Hormone Receptor beta Antibody

    交叉反应 (详细)

    Thyroid Hormone Receptor beta antibody is purified by Protein G chromatography from cell culture supernatant.

    纯化方法

    Anti-Thyroid Hormone Receptor beta antibody is directed against human TRβ.

    免疫原

    Anti-Thyroid Hormone Receptor beta monoclonal antibody was produced in mouse by repeated immunizations with synthetic peptide corresponding to amino acid residues from the N-terminal region of Thyroid Hormone Receptor beta.

    亚型

    IgG1
  • 应用备注

    Optional[Neutralization_Dilution]: 1:1000

    说明

    Suggested Applications: IHC
    Anti-Thyroid Hormone Receptor beta (Mouse) antibody is tested for use in Western Blotting. Expect a band of approximately 55 kDa corresponding to TR-β proteins in the appropriate cell lysate or extract. Researchers should determine optimal titers for applications that are not stated below.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    储存条件

    4 °C,-20 °C

    储存方法

    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

    有效期

    12 months
  • Aksoy, Pencik, Hartenbach, Moazzami, Schlederer, Balber, Varady, Philippe, Baltzer, Mazumder, Whitchurch, Roberts, Haitel, Herac, Susani, Mitterhauser, Marculescu, Stangl-Kremser, Hassler, Kramer, Shariat, Turner, Tichy, Oppelt, Pospisilova, Hartenbach, T: "Thyroid and androgen receptor signaling are antagonized by μ-Crystallin in prostate cancer." in: International journal of cancer, Vol. 148, Issue 3, pp. 731-747, (2021) (PubMed).

    Schnoell, Kotowski, Jank, Stoiber, Gurnhofer, Schlederer, Heiduschka, Kenner, Kadletz-Wanke: "Prognostic Relevance of Thyroid-Hormone-Associated Proteins in Adenoid Cystic Carcinoma of the Head and Neck." in: Journal of personalized medicine, Vol. 11, Issue 12, (2021) (PubMed).

  • 抗原

    THRB (Thyroid Hormone Receptor, beta (THRB))

    别名

    Thyroid Hormone Receptor beta

    背景

    Synonyms: mouse anti-Thyroid Hormone Receptor beta Antibody, mouse anti-Thrb antibody, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta

    Background: Thyroid Hormone Receptor beta antibody detects Thyroid Hormone Receptor beta. Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain. Thyroid Hormone Receptor beta antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.

    Gene Name: THRB

    基因ID

    7068

    NCBI登录号

    NP_000452

    UniProt

    P10828

    途径

    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound
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