Progesterone Receptor 抗体 (pSer294)
Quick Overview for Progesterone Receptor 抗体 (pSer294) (ABIN6655216)
抗原
See all Progesterone Receptor (PGR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer294
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Supplier Product No.
- 209-301-e17
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Supplier
- Rockland
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原理
- Progesterone Receptor phospho S294 Antibody
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纯化方法
- Anti-Progesterone Receptor pS294 (Mouse) Monoclonal Antibody is Protein G purified from cell culture supernatant. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
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免疫原
- Anti-Progesterone Receptor pS294 (Mouse) Monoclonal Antibody was produced in mouse by repeated immunizations with Progesterone Receptor pS294- Synthetic peptide corresponding to amino acid residues surrounding Ser294 of the human progesterone receptor protein.
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亚型
- IgG1
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anti-Progesterone Receptor (PGR) (AA 1-110) antibody
PGR 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-Progesterone Receptor (PGR) (AA 166-411) antibodyPGR 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2E9F2 unconjugated
anti-Progesterone Receptor (PGR) (AA 166-411) antibodyPGR 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2E4B9 unconjugated
anti-Progesterone Receptor (PGR) antibodyPGR 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 1-250) antibodyPGR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 501-600) antibodyPGR 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (pSer190) antibodyPGR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 483-571) antibodyPGR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PGR-2694 unconjugated
anti-Progesterone Receptor (PGR) (pSer400) antibodyPGR 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (pSer294) antibodyPGR 适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry_Dilution: 1:1000
Western_Blot_Dilution: 1:1000
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说明
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Anti-Progesterone Receptor pS294 (Mouse) antibody is tested for use in Western Blotting and IHC. Specific conditions for reactivity should but optimized by the end user. Expect a band of approximately 90 kDa in size for PR-A isoform and the approximately 120 kDa PR-B isoform phosphorylated at Ser294.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- Progesterone Receptor (PGR)
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别名
- Progesterone Receptor
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背景
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Synonyms: mouse anti-Progesterone Receptor phospho S294 Antibody, mouse anti-Progesterone Receptor pS294 antibody, PR, Nuclear receptor subfamily 3 group C member 3
Background: There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor. Anti-Progesterone Receptor pS294 (Mouse) Monoclonal Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Cancer research.
Gene Name: PGR
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基因ID
- 5241
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UniProt
- P06401
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途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
抗原
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