HSPH1 抗体
Quick Overview for HSPH1 抗体 (ABIN6655020)
抗原
See all HSPH1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
Supplier Product No.
- 600-401-f52
-
Supplier
- Rockland
-
原理
- Hsp110 Antibody
-
交叉反应 (详细)
- A BLAST analysis was used to suggest cross-reactivity with Hsp110 from Human, Monkey, Hamster, Rat, Mouse, Cow, Sheep, and Yeast based on 100 % homology with the immunizing sequence.
-
纯化方法
- Anti-Hsp110 Antibody was purified by affinity chromatography.
-
过滤
- Sterile filtered
-
免疫原
- Hsp110 Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against a synthetic peptide derived from the sequence of hamster Hsp110.
-
亚型
- IgG
-
-
-
-
应用备注
-
Immunohistochemistry_Dilution: 1:100
IF_Microscopy_Dilution: User Optimized
Western_Blot_Dilution: 1:1000
-
说明
-
Anti-Hsp110 Antibody is tested for use in WB, IHC, and IF/ICC. Expect a band approximately ~110kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
-
Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
Preservative: 0.1 % (w/v) Sodium Azide -
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
-
有效期
- 12 months
-
-
- HSPH1 (Heat Shock 105kDa/110kDa Protein 1 (HSPH1))
-
别名
- HSPH1
-
背景
-
Synonyms: Heat shock 105 kDa alpha, heat shock 105 kDa beta, Hsp105, Hsp105A, Hsp105B, Hsp110, HSPH1, NY CO 25, Heat shock 110 kDa protein
Background: Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33 % amino acid identity, mostly in the conserved ATP-binding domain. Hsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol. In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain. Both Hsp70 and Hsp110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70. Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy.
Gene Name: HSPH1
-
基因ID
- 100689462
-
NCBI登录号
- NP_001233649
-
UniProt
- Q60446
抗原
-