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CA8 抗体

This anti-CA8 antibody is a 小鼠 单克隆 antibody detecting CA8 in WB 和 IHC (p). Suitable for 人.
产品编号 ABIN6654758
发货至: 中国

Quick Overview for CA8 抗体 (ABIN6654758)

抗原

See all CA8 抗体
CA8 (Carbonic Anhydrase VIII (CA8))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CA8 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

CPTC-CA8-2
  • 纯化方法

    Purified

    纯度

    Protein G affinity

    免疫原

    Full length recombinant human protein was used as the immunogen for the CA8 antibody.

    亚型

    IgG2a
  • 应用备注

    Optimal dilution of the CA8 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)

    限制

    仅限研究用
  • 缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the CA8 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原

    CA8 (Carbonic Anhydrase VIII (CA8))

    别名

    CA8 / Carbonic Anhydrase VIII

    背景

    The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 (carbonic anhydrase 8) gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.
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