MITF 抗体
Our Local Distributor
北京 101111
Quick Overview for MITF 抗体 (ABIN6654666)
抗原
See all MITF 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- Purified
-
纯度
- Protein A affinity chromatography
-
免疫原
- Recombinant full-length human protein was used as the immunogen for the recombinant MITF antibody.
-
亚型
- IgG kappa
-
-
-
-
应用备注
-
The stated application concentrations are suggested starting points. Titration of the recombinant MITF antibody may be required due to differences in protocols and secondary/substrate sensitivity.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) -
限制
- 仅限研究用
-
-
-
缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
-
储存液
- Azide free
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store the recombinant MITF antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
-
-
- MITF (Microphthalmia-Associated Transcription Factor (MITF))
-
别名
- MITF
-
背景
- MITF (microphthalmia transcription factor) is a transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. [UniProt]
-
途径
- Chromatin Binding
抗原
-