BCL10 抗体 (AA 122-168)
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北京 101111
Quick Overview for BCL10 抗体 (AA 122-168) (ABIN6654586)
抗原
See all BCL10 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 122-168
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纯化方法
- Purified
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纯度
- Protein A affinity chromatography
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免疫原
- A portion of amino acids 122-168 from the human protein was used as the immunogen for this recombinant Bcl10 antibody.
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亚型
- IgG kappa
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应用备注
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The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant Bcl10 antibody to be titered up or down for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) -
限制
- 仅限研究用
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the recombinant Bcl10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- BCL10 (B-Cell CLL/lymphoma 10 (BCL10))
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别名
- Bcl10
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背景
- Bcl10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1,14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of Bcl10 was shown to induce NFkB activation in a NIK-dependent pathway. This antibody labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1,14) translocation, while 55 % of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
抗原
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