HAVCR1 抗体 (AA 58-289)
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Quick Overview for HAVCR1 抗体 (AA 58-289) (ABIN6654049)
抗原
See all HAVCR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 58-289
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纯化方法
- Antigen affinity purified
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免疫原
- Amino acids Q58-K289 from the human protein were used as the immunogen for the TIM1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TIM1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,ELISA (Capture): 1-5 μg/mL (human recombinant protein)
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the TIM1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
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别名
- KIM-1 / TIM-1 / HAVCR1
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物质类
- Virus
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背景
- KIM1 (KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that TIM1 is capable of homophilic Tim-Tim interactions. The protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, TIM1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of TIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. TIM1-expressing epithelial cells internalized apoptotic bodies, and the protein is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.
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UniProt
- Q96D42
抗原
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