GDF5 抗体 (AA 361-410)
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北京 101111
Quick Overview for GDF5 抗体 (AA 361-410) (ABIN6579619)
抗原
See all GDF5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 361-410
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原理
- GDF-5 Antibody
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特异性
- GDF-5 Polyclonal Antibody detects endogenous levels of GDF-5 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5. AA range:361-410
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- GDF5 (Growth Differentiation Factor 5 (GDF5))
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别名
- GDF5
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背景
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Synonyms: GDF5, CDMP1, Growth/differentiation factor 5, GDF-5, Cartilage-derived morphogenetic protein 1, CDMP-1, Radotermin
Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations in this gene are associated with acromesomelic dysplasia, brachydactyly, chondrodysplasia, multiple synostoses syndrome, proximal symphalangism, and susceptibility to osteoarthritis. [provided by RefSeq, Aug 2016],
Gene Name: GDF5
Protein Name: Growth/differentiation factor 5
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分子量
- 55 kDa
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基因ID
- 8200
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OMIM
- 601146
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UniProt
- P43026
抗原
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