L3MBTL1 抗体 (AA 1-215)
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Quick Overview for L3MBTL1 抗体 (AA 1-215) (ABIN6579167)
抗原
See all L3MBTL1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-215
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原理
- L3MBTL1 antibody (pAb)
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纯化方法
- Unpurified
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免疫原
- This L3MBTL1 antibody was raised against a His-Tagged fusion protein corresponding to amino acids 1-215 of human L3MBTL1.
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anti-L(3)mbt-Like 1 (L3MBTL1) (Center) antibody
L3MBTL1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 1-772) antibodyL3MBTL1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 82-298) antibodyL3MBTL1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 451-485) antibodyL3MBTL1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB53645 unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 513-752) antibodyL3MBTL1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (N-Term) antibodyL3MBTL1 适用: 人, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 442-491) antibodyL3MBTL1 适用: 人, 小鼠, 犬, 大鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 221-270) antibodyL3MBTL1 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-L(3)mbt-Like 1 (L3MBTL1) (AA 144-193) antibodyL3MBTL1 适用: 人, 豚鼠, 兔, 马, Cow WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB*: 1:500 - 1:2,000 dilution *Note: many chromatin-bound proteins are not soluble in a low salt nuclear extract and fractionate to the pellet. Therefore, we recommend a High Salt / Sonication Protocol when preparing nuclear extracts for Western blot.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit serum containing 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage
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储存条件
- -20 °C
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储存方法
- Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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有效期
- 24 months
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: "Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27767-75, (2010) (PubMed).
: "Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development." in: Nature, Vol. 466, Issue 7305, pp. 503-7, (2010) (PubMed).
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- L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))
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别名
- L3MBTL1
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背景
- L3MBTL1 is a human homolog of the Drosophila l(3)mbt protein. Located on chromosome 20q12, L3MBT1 is a member of the malignant brain tumor (MBT) protein family and directly compacts chromatin in a strictly histone methylation dependent fashion. L3MBTL1 functions as a transcriptional repressor in a manner that requires its three MBT domains, which were predicted to bind methylated lysines of histones. L3MBTL1 binds to Lys20 of Histone H4 that has been mono- or dimethylated, as well as to Histone H1 isotype b methylated at lysine 26. L3MBTL1 is a complex molecule with a Zinc-finger and a sterile alpha motif (SAM).
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分子量
- 100 kDa
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基因ID
- 26013
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NCBI登录号
- NP_056293
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途径
- Chromatin Binding
抗原
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