Nemo-Like Kinase 抗体 (C-Term)
Quick Overview for Nemo-Like Kinase 抗体 (C-Term) (ABIN657850)
抗原
See all Nemo-Like Kinase (NLK) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 408-436, C-Term
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预测反应
- B, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Nlk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 408-436 amino acids from the C-terminal region of mouse Nlk.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Mouse Nlk Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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有效期
- 6 months
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- Nemo-Like Kinase (NLK)
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别名
- Nlk
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背景
- Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP. Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
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分子量
- 58313
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基因ID
- 100044468, 18099
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NCBI登录号
- NP_032728
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UniProt
- O54949
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途径
- Ubiquitin Proteasome Pathway
抗原
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