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TSG101 抗体

This anti-TSG101 antibody is a 小鼠 单克隆 antibody detecting TSG101 in WB, IP, IF/ICC, PLA 和 BP. Suitable for 人.
产品编号 ABIN190317
发货至: 中国

Quick Overview for TSG101 抗体 (ABIN190317)

抗原

See all TSG101 抗体
TSG101 (Tumor Susceptibility Gene 101 (TSG101))

适用

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宿主

  • 68
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小鼠

克隆类型

  • 57
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单克隆

标记

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This TSG101 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC), Proximity Ligation Assay (PLA), Blocking Peptide (BP)

克隆位点

1F3
  • 原理

    Anti-DNA Ligase III Mouse Monoclonal Antibody

    特异性

    This antibody recognizes human, mouse, and chicken DNA Ligase III. Cellular localization is nuclear and mitochondrial.

    交叉反应

    小鸡, 人, 小鼠

    免疫原

    Full-length recombinant human DNA Ligase III-b.

    亚型

    IgG1
  • 应用备注

    Immunoblotting: use at 0.5-2 μg/mL. Predicted molecular weight ~100 kDa.
    These are recommended concentrations.
    Endusers should determine optimal concentrations for their applications.

    限制

    仅限研究用
  • 状态

    Liquid

    溶解方式

    Dilute in PBS or medium which is identical to that used in the assay system.

    浓度

    1.0 mg/mL

    缓冲液

    Hybridoma culture supernatant

    储存条件

    -20 °C

    储存方法

    This antibody is stable for at least one year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.
  • 抗原

    TSG101 (Tumor Susceptibility Gene 101 (TSG101))

    别名

    TSG101

    背景

    DNA ligase 3,Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {PubMed:10207110, PubMed:24674627}.,There are four distinct ligase proteins found in mammalian cells. These DNA ligases are required for joining DNA strand breaks that occur during DNA replication, repair and recombination. DNA Ligase III is a 100 kDa (a-form) protein in somatic tissues, is ubiquitously expressed, and complexes with XRCC-1 and a 97 kDa ( -form) protein that is found in testis. DNA Ligase III is involved in rejoining DNA single-strand breaks and in base excision repair pathway.,[Isoform 1]: Mitochondrion,EC 6.5.1.1, DNA ligase III, Polydeoxyribonucleotide synthase [ATP] 3

    UniProt

    P49916
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