FGD4 抗体
Quick Overview for FGD4 抗体 (ABIN6571864)
抗原
See all FGD4 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human FGD4
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亚型
- IgG
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anti-FYVE, RhoGEF and PH Domain Containing 4 (FGD4) antibody
FGD4 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-FYVE, RhoGEF and PH Domain Containing 4 (FGD4) (AA 99-198) antibodyFGD4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))
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别名
- FGD4
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背景
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Synonyms: 9030023J02Rik,9330209B17Rik,Actin filament binding protein frabin,Actin filament-binding protein frabin,CMT4H,DKFZp313E1818,DKFZp434K1572,FGD1 related F actin binding protein,FGD1-related F-actin-binding protein,Fgd4,FGD4,FLJ34370,FLJ42663,FRABP,FYVE,FYVE, RhoGEF and PH domain containing 4,MGC57222,RhoGEF and PH domain-containing protein 4,ZFYVE6,Zinc finger FYVE domain containing protein 6,Zinc finger FYVE domain-containing protein 6
Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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分子量
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Observed_MW: 100kDa
Calculated_MW: 20kDa/32kDa/86kDa
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基因ID
- 121512
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UniProt
- Q96M96
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途径
- Neurotrophin Signaling Pathway
抗原
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