WISP2 抗体
Quick Overview for WISP2 抗体 (ABIN6571151)
抗原
See all WISP2 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human WISP2
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- WISP2 (WNT1 Inducible Signaling Pathway Protein 2 (WISP2))
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别名
- WISP2
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背景
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Synonyms: CCN family member 5,CCN5,Connective tissue growth factor like protein,Connective tissue growth factor related protein 58,Connective tissue growth factor-like protein,Connective tissue growth factor-related protein 58,CT58,CTGF L,CTGF-L,WISP 2,WISP-2,Wisp2,WISP2,Wnt 1 signaling pathway protein 2,WNT1 inducible signaling pathway protein 2,WNT1-inducible-signaling pathway protein 2
Background: This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72 % identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
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分子量
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Observed_MW: 27kDa
Calculated_MW: 22kDa/26kDa
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基因ID
- 8839
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UniProt
- O76076
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途径
- WNT signaling, Growth Factor Binding
抗原
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