DUSP4 抗体
Quick Overview for DUSP4 抗体 (ABIN6569333)
抗原
See all DUSP4 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Affinity purification
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免疫原
- Recombinant protein of human DUSP4
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- DUSP4 (Dual Specificity Phosphatase 4 (DUSP4))
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别名
- MKP-2
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背景
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Synonyms: Dual specificity phosphatase 4,Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,DUS4,DUSP 4,Dusp4,HVH 2,HVH2,MAP kinase phosphatase 2,Mitogen activated protein kinase phosphatase 2,Mitogen-activated protein kinase phosphatase 2,MKP 2,MKP-2,MKP2,Serine/threonine specific protein phosphatase,TYP,Typ1,VH 2,VH1 homologous phosphatase 2,VH2
Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.
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分子量
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Observed_MW: 43kDa
Calculated_MW: 32kDa/42kDa
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基因ID
- 1846
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UniProt
- Q13115
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途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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