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SFPQ 抗体

The 兔 多克隆 anti-SFPQ antibody is suitable to detect SFPQ in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC 和 IF.
产品编号 ABIN6566706
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SFPQ 抗体 (ABIN6566706)

抗原

See all SFPQ 抗体
SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

适用

  • 61
  • 33
  • 29
  • 7
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
人, 小鼠, 大鼠

宿主

  • 56
  • 5

克隆类型

  • 36
  • 25
多克隆

标记

  • 33
  • 4
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This SFPQ antibody is un-conjugated

应用范围

  • 47
  • 26
  • 25
  • 17
  • 14
  • 9
  • 8
  • 5
  • 3
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
  • 纯化方法

    Affinity purification

    免疫原

    Recombinant fusion protein of human SFPQ (NP_005057.1).

    亚型

    IgG
  • 应用备注

    WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

    别名

    SFPQ

    背景

    DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells, T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A.

    分子量

    Observed_MW: 115kDa

    Calculated_MW: 72kDa/76kDa

    基因ID

    6421

    UniProt

    P23246
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