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TRIM72 抗体 (C-Term)

This anti-TRIM72 antibody is a 兔 多克隆 antibody detecting TRIM72 in WB 和 IHC (p). Suitable for 人, 大鼠 和 小鼠.
产品编号 ABIN655919
发货至: 中国

Quick Overview for TRIM72 抗体 (C-Term) (ABIN655919)

抗原

See all TRIM72 抗体
TRIM72 (Tripartite Motif Containing 72 (TRIM72))

适用

  • 26
  • 8
  • 7
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
人, 大鼠, 小鼠

宿主

  • 20
  • 5
  • 2

克隆类型

  • 24
  • 3
多克隆

标记

  • 20
  • 2
  • 2
  • 1
  • 1
  • 1
This TRIM72 antibody is un-conjugated

应用范围

  • 24
  • 15
  • 13
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB29696
  • 抗原表位

    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 299-327, C-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:2000. IHC-P: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • 抗原

    TRIM72 (Tripartite Motif Containing 72 (TRIM72))

    别名

    TRIM72

    背景

    TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

    分子量

    52731

    基因ID

    493829

    NCBI登录号

    NP_001008275

    UniProt

    Q6ZMU5
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