DHCR7 抗体 (C-Term)
Quick Overview for DHCR7 抗体 (C-Term) (ABIN655399)
抗原
See all DHCR7 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 437-463, C-Term
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This DHCR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-463 amino acids from the C-terminal region of human DHCR7.
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亚型
- Ig Fraction
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anti-7-Dehydrocholesterol Reductase (DHCR7) (AA 1-475) antibody
DHCR7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-7-Dehydrocholesterol Reductase (DHCR7) (AA 63-147) antibodyDHCR7 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-7-Dehydrocholesterol Reductase (DHCR7) (AA 351-450) antibodyDHCR7 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- IF: 1:25. IF: 1:10~50. WB: 1:2000. WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- DHCR7 (7-Dehydrocholesterol Reductase (DHCR7))
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别名
- DHCR7
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背景
- This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS), a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.
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分子量
- 54489
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基因ID
- 1717
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NCBI登录号
- NP_001157289, NP_001351
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UniProt
- Q9UBM7
抗原
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