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FBXW8 抗体 (AA 270-299)

This 兔 多克隆 antibody specifically detects FBXW8 in WB, FACS 和 IHC (p). It exhibits reactivity toward 人 和 小鼠.It has been mentioned in 1 publication
产品编号 ABIN654676
发货至: 中国
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Quick Overview for FBXW8 抗体 (AA 270-299) (ABIN654676)

抗原

See all FBXW8 抗体
FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))

适用

  • 17
  • 16
  • 8
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
人, 小鼠

宿主

  • 30
  • 1

克隆类型

  • 31
多克隆

标记

  • 12
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This FBXW8 antibody is un-conjugated

应用范围

  • 30
  • 13
  • 13
  • 13
  • 8
  • 7
  • 4
  • 3
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB28550
  • 抗原表位

    • 15
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 270-299

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This FBXW8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-299 amino acids from the Central region of human FBXW8.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

    有效期

    6 months
  • Wang, Chen, Lin, Li, Zhou, Liu, Logsdon, Jin, Abbruzzese, Tan, Wang: "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 289, Issue 7, pp. 4009-17, (2014) (PubMed).

  • 抗原

    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))

    别名

    FBXW8

    背景

    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

    分子量

    67394

    基因ID

    26259

    NCBI登录号

    NP_036306, NP_699179

    UniProt

    Q8N3Y1
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