This anti-SREBF chaperone antibody is a 兔 多克隆 antibody detecting SREBF chaperone in WB, IF, IHC (p) 和 FACS. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 1 publication.
This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This SCAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 604-632 amino acids from the Central region of human SCAP.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C,-20 °C
储存方法
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
有效期
6 months
Takashima, Saitoh, Funabashi, Hirose, Yagi, Nozaki, Sato, Shin, Nakayama: "COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions." in: Journal of cell science, Vol. 128, Issue 15, pp. 2805-15, (2015) (PubMed).
抗原
SREBF chaperone (SCAP)
别名
SCAP
背景
SCAP is a protein with a sterol sensing domain(SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.