NFkB 抗体 (pSer536)
Quick Overview for NFkB 抗体 (pSer536) (ABIN650886)
抗原
See all NFkB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer536
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预测反应
- M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This NF kappa B Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NF kappa B.
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亚型
- Ig Fraction
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anti-Nuclear Factor kappa B (NFkB) (AA 42-367) antibody
NFkB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 805-892) antibodyNFkB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 352-439) antibodyNFkB 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 40-365) antibodyNFkB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) antibodyKD Validated NFkB 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
anti-Nuclear Factor kappa B (NFkB) antibodyNFkB 适用: 人 CP unconjugated
anti-Nuclear Factor kappa B (NFkB) (AA 47-372) antibodyNFkB 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor kappa B (NFkB) (pSer536) antibodyNFkB 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB5212 unconjugated
anti-Nuclear Factor kappa B (NFkB) (pSer536) antibodyNFkB 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- DB: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- NFkB (Nuclear Factor kappa B (NFkB))
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别名
- NF kappa B
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背景
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
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分子量
- 60219
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基因ID
- 5970
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NCBI登录号
- NP_001138610, NP_001230913, NP_068810
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UniProt
- Q04206
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途径
- Ubiquitin Proteasome Pathway, S100 Proteins
抗原
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