PTRH2 抗体 (AA 80-110)
Quick Overview for PTRH2 抗体 (AA 80-110) (ABIN650622)
抗原
See all PTRH2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 80-110
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 amino acids from the Central region of human Bit1.
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亚型
- Ig Fraction
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anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibody
PTRH2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibodyPTRH2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 26-55), (N-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal RB42733 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 100-149) antibodyPTRH2 适用: 人, Cow, 犬, 豚鼠, 马, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (C-Term) antibodyPTRH2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (N-Term) antibodyPTRH2 适用: 人, 小鼠, 大鼠 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (Middle Region) antibodyPTRH2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:10~50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
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别名
- Bit1
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背景
- Adhesion to extracellular matrix regulates cell survival via integrin engagement and cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. A role for Bit1 (Bcl-2 inhibitor of transcription 1) has been identified in this process. Bit1 is a mitochondrial protein released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. Bit1-AES complexes may switch off a survival-promoting gene transcription program controlled by TLE. Apoptosis of Bit1/AES transfected cells is inhibited when cells are permitted to attach to fibronectin through the alpha-beta integrin, suggesting that the contribution of the Bit1-AES pathway to anoikis is regulated by integrins.
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分子量
- 19194
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基因ID
- 51651
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NCBI登录号
- NP_057161
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UniProt
- Q9Y3E5
抗原
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