Shiga Toxin 1 & 2 (Stx-1, Stx-2) 抗体
Stx-1, Stx-2
适用: E. coli
宿主: 小鼠
unconjugated
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- 抗原
- Shiga Toxin 1 & 2 (Stx-1, Stx-2)
- 适用
- E. coli
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宿主
- 小鼠
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标记
- 非结合性
- 应用范围
- 请咨询
- 特异性
- Reacts with Escherichia coli (E. coli) Shigatoxin (STX) 1 and 2
- 产品特性
- Mouse Anti-E. coli STX 1 & 2
- 纯化方法
- Purified
- 亚型
- IgG
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 1ml deionized water.
- 浓度
- 1 mg/ml (prior to lyophilization)
- 缓冲液
- Lyophilized from 5mM Phosphate buffer, pH 7.2 - 7.4
- 储存条件
- 4 °C
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- 抗原
- Shiga Toxin 1 & 2 (Stx-1, Stx-2)
- 背景
- Monoclonal Antibody to Escherichia coli (E. coli) Shigatoxin (STX) 1 and 2, pooled IgGThe baculovirus protein p35 inhibits virally induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the host's immune system. This is accomplished at least in part by its ability to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino terminal baculovirus IAP repeat (BIR) motif and a carboxy terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtublules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.
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