Natural Killer Cells 抗体
The 小鼠 单克隆 anti-Natural Killer Cells antibody is suitable to detect Natural Killer Cells in samples from 小鼠. It has been validated for Func, FACS 和 IP.
产品编号 ABIN642458
发货至:
中国
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Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Natural Killer Cells 抗体 (ABIN642458)
抗原
Natural Killer Cells
适用
小鼠
宿主
小鼠
克隆类型
单克隆
应用范围
Functional Studies (Func), Flow Cytometry (FACS), Immunoprecipitation (IP)
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原理
- Mouse Anti-Mouse NK-1.1 Ag.
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特异性
- DS-MB-02011 recognizes the mouse NK1.1 cell surface antigen, a cell surface glycoprotein encoded by members of the NKR-P1 gene family.In the mouse the NKR-P1 family has three members, NKR-P1A, -B and -C, whilst in the human only one member has been identified. The human protein has received the designation CD161, and the mouse proteins have been referred to as CD161a, -b, -c etc. Although previously thought to recognize only CD161c, recent data has shown that this antibody may also react with CD161b. CD161c expression itself is strain specific in mice, but recognition of CD161b by DS-MB-2011 appears to be even more complex, as only some CD161b positive strains are labeled by the antibody. Engagement of CD161c has been reported to have activating function in NK cells, whilst engagement of CD161b is inhibitory. DS-MB-02011 is useful for the identification of NK cells in selected strains of mice (positive on C57BL, FVB/N and NZB, but negative on AKR and BALB/c) and is also expressed by rare subsets of T cells and monocytes. The antibody has also been used for in vivo depletion of NK cells and in vitro activation of NK cells.
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免疫原
- Spleen and bone marrow cells from CE mice
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亚型
- IgG2a
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应用备注
- Flow Cytometry, Functional Assays, Immunoprecipitation
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限制
- 仅限研究用
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浓度
- IgG concentration 1.0 mg/ml
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缓冲液
- Phosphate buffered saline, pH 7.4
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- -20°C
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- Natural Killer Cells
抗原
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