HCV E2
适用: Hepatitis C Virus (HCV)
WB, EIA, IFA
宿主: 小鼠
Monoclonal
unconjugated
限制
仅限研究用
状态
Liquid
浓度
4-5 mg/ml (OD280nm, E^0.1% = 1.4)
缓冲液
0.01M PBS, pH 7.2
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
抗原
HCV E2
(Hepatitis C Virus Envelope Protein E2 (HCV E2))
物质类
Viral Protein
背景
Uev1A, also designated Uev1, UBE2V1 (for ubiquitin-conjugating enzyme E2 variant 1) and CROC1, shows sequence similarity to other ubiquitin-conjugating enzymes, but lacks the conserved cysteine residue critical for their catalytic activity. Therefore, Uev1A does not have ubiquitin-conjugating activity in vitro. However, constitutive expression of exogenous Uev1A in colon carcinoma cells inhibits their capacity to differentiate upon confluence. Studies on recombinant Uev1A show that it localizes to the nucleus, excluding the nucleolar regions. Uev1A functions with TRAF6, a RING domain protein, to catalyze the synthesis of unique polyubiquitin chains linked through Lysine 63 of ubiquitin. The gene encoding Uev1A maps to human chromosome 20q13.2.