Adipolean (Variant) 抗体
适用: 人
ELISA, WB, Inhibition
宿主: 兔
Polyclonal
unconjugated
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- 抗原
- Adipolean
- 抗原表位
- Variant
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
- 应用范围
- ELISA, Western Blotting (WB), Blocking Antibody (Inhibition)
- 纯化方法
- Purified
- 免疫原
- Adipolean Variant antibody was raised in rabbit using highly pure recombinant human adipolean variant as the immunogen.
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- 应用备注
- Optimal conditions should be determined byt he investigator.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from PBS, pH 7.2.
- 注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. - 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
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- 抗原
- Adipolean
- 背景
- The adipolean variant is an important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. The adipolean variant antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It also inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway.
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