TYMS 抗体 (C-Term)
Quick Overview for TYMS 抗体 (C-Term) (ABIN631290)
抗原
See all TYMS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- TYMS antibody was raised against the C terminal of TYMS
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纯化方法
- Affinity purified
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免疫原
- TYMS antibody was raised using the C terminal of TYMS corresponding to a region with amino acids HIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKME
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应用备注
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WB: 0.25 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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TYMS Blocking Peptide, (ABIN939139), is also available for use as a blocking control in assays to test for specificity of this TYMS antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of TYMS antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- TYMS (Thymidylate Synthetase (TYMS))
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别名
- TYMS
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背景
- TYMS catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
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分子量
- 36 kDa (MW of target protein)
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途径
- Mitotic G1-G1/S Phases
抗原
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