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Integrin beta 4 抗体

ITGB4 适用: 人 FACS, IF, Func, BP 宿主: 小鼠 Monoclonal unconjugated
产品编号 ABIN6297743
发货至: 中国
  • 抗原 See all Integrin beta 4 (ITGB4) 抗体
    Integrin beta 4 (ITGB4)
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Integrin beta 4 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func), Blocking Peptide (BP)
    原理
    Mouse anti-Human Integrin Beta-4 Antibody [Sodium Azide Free]
    特异性
    Cell surface
    纯化方法
    The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.
    免疫原
    The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta-4 / CD104 antibody.
    Top Product
    Discover our top product ITGB4 Primary Antibody
  • 应用备注
    Functional Blocking: partially blocks laminin binding, order the BSA/azide free format
    FACS: 0.5-1 μg/million cells
    IF: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    In 1X PBS ( pH 7.4), BSA free, sodium azide free
    储存液
    Azide free
    储存条件
    4 °C,-20 °C
    储存方法
    2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
  • 抗原
    Integrin beta 4 (ITGB4)
    别名
    Integrin beta-4 (ITGB4 产品)
    别名
    AA407042 antibody, C230078O20 antibody, CD104 antibody, integrin subunit beta 4 antibody, integrin beta 4 antibody, ITGB4 antibody, Itgb4 antibody
    背景

    Target Description: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of < font face=symbol>a and < font face=symbol>b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of < font face=symbol>a and < font face=symbol>b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

    Gene Symbol: ITGB4

    基因ID
    3691
    UniProt
    P16144
    途径
    Integrin Complex
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